An overview of Botox treatment for migraines


A migraine refers to a specific type of headache: this headache is a unilateral (one sided), pulsating, or throbbing headache that lasts anywhere from two to four hours, and can be Botox for Migrainesassociated with an “aura” of associated symptoms, such as nausea, vomiting, photophobia (sensitivity to light), and transient neurological symptoms.

This pain is typically recurring, and can be associated with specific triggers that the patient can identify. The headache from migraine is also aggravated by external stimuli, such as loud sounds, bright lights, and physical activity.

Migraine affects a significant portion of the global population, going as high as 15 percent in some estimates. The prevalence among women (19 percent) is significantly higher than that among men (11 percent).

Migraine Specialist PhoenixThe cause of migraine has many theories. Some researchers point to the increased excitability of the cerebral cortex and abnormal firing of pain neurons in the trigeminal nucleus. Changes in serotonin levels have also been observed, and these can cause spasms and dilations of the blood vessels in the brain, causing the headache. Hormonal changes, food, environment, and emotional stressors have also been implicated in triggering migraine.

Typically, migraine is managed using medications, such as painkillers. There is a stepwise progression in painkillers, with non-steroidal anti-inflammatory drugs (NSAIDs) being prescribed prior to opioid analgesics. Prophylactic medication with topimarate, propranolol, metoprolol and sodium valproate have been shown to reduce the frequency and severity of attacks for those with chronic migraine.

One of the more recent novel interventions for treatment of migraine is the injection of Botulinum toxin type A, or “botox” as it is colloquially known. Botox is a purified form of neurotoxin that is produced by the bacterium Clostridium botulinum, which works by interfering in the transmission of signals between the nerve and muscle. Botox causes local Migraine clinic Phoenixmuscle paralysis, and its use in dermatologic procedures to smooth out wrinkles is widely known.

Researchers have found that injections with Botulinum toxin are effective in reducing the frequency of headaches, as well as significantly improving the patient’s quality of life. This seems to be the best application for Botox, as it has not been shown to be better than placebo in the treatment of acute headaches.

The injections have been proven to be generally well tolerated by patients, with neck pain appearing in 9 percent of patients. Other side effects of the injections include itching, pain in the injection site, as well as muscle aching, tightness, or spasms.

It is still not understood how botulinum toxin provides effective reduction in the frequency and severity of migraines. There have been several theories offered, and these include:Pain clinic Phoenix

  • Botulinum toxin causes local muscle paralysis. This relaxation of the muscles around the head may reduce blood pressure within the brain. It may also decrease muscular spasm, a possible cause of the headache.
  • Botulinum toxin may interfere with the ability of the nerves to send pain signals
  • Botulinum toxin may directly interfere with the transmission of signals that triggers an attack of migraine

Botox works, however, it should be reserved until initial therapy with oral medications has failed.

The top headache specialists in AZ are with Arizona Pain Specialists. The Board Certified pain management doctors in Arizona at the practice provide both medical and interventional treatments. This includes occipital blocks, Botox for migraines, abortive and preventive medications.

Over 50 insurances are accepted at any of the 7 Arizona Pain locations. Call (602) 507-6550 for schedule you or a loved one right away!


Lin KH, Chen SP, Fuh JL, Wang YF, Wang SJ. Efficacy, safety, and predictors of response to botulinum toxin type A in refractory chronicmigraine: a retrospective study. J Chin Med Assoc. 2014 Jan;77(1):10-5. doi: 10.1016/j.jcma.2013.09.006.

Reddy DS. The pathophysiological and pharmacological basis of current drug treatment of migraine headache. Expert Rev Clin Pharmacol. 2013 May;6(3):271-88. doi: 10.1586/ecp.13.14.

Shao YF, Zhang Y, Zhao P, et al. Botulinum toxin type a therapy in migraine: preclinical and clinical trials. Iran Red Crescent Med J. 2013 Oct;15(10):e7704. doi: 10.5812/ircmj.7704.

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